ICA1

Across TCGA cell cohorts, ICA1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ICA1-associated genes across cancer lineages are TPPP2, RLN3, and ODF4. Each is linked with ICA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ICA1-to-partner and partner-to-ICA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TPPP2 grouped by ICA1-low versus ICA1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICA1→partner) and Y-score (partner→ICA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TPPP2 →	+0.168	+4.930	<.001	.008	3	1
SKIN	RLN3 →	+0.063	+4.977	<.001	.007	3	1
SKIN	ODF4 →	+0.031	+4.977	<.001	.007	3	1
SKIN	NCR2 →	+0.020	+6.022	<.001	.001	3	1
LARGE_INTESTINE	FAM205A →	+0.030	+4.614	<.001	.002	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

TPPP2 by ICA1 expression — SOFT_TISSUE

Explore this box plot interactively →