IBA57

Across TCGA patient cohorts, IBA57 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IBA57-associated genes across cancer lineages are FOXO3a_pS318_S321, GAPDH, and Ku80. Each is linked with IBA57 in more than 1 cancer types. Because this analysis shows association rather than direction, both IBA57-to-partner and partner-to-IBA57 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by IBA57-low versus IBA57-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IBA57→partner) and Y-score (partner→IBA57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.155	-3.160	.023	.019	3	1
UCEC	GAPDH →	+0.722	+2.999	.014	.035	3	1
UCEC	Ku80 →	+0.353	+2.817	.006	.036	3	1
UCEC	p62 Lck ligand →	+0.544	+3.009	.002	.019	3	1
UCEC	TIGAR →	+0.182	+3.196	.030	.010	3	1
UCEC	ASNS →	+0.675	+3.000	<.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

FOXO3a_pS318_S321 by IBA57 expression — UCEC

Explore this box plot interactively →