Across TCGA pan-cancer cohorts, IARS1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IARS1 data layer compared with 18 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IARS1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IARS1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

LUAD, OV, and CCRCC are the cancer types where IARS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	II,III,IV	0.190	0.764	<.001	17	view →
OV	DFS	Median	All	0.871	1.000	.048	4	view →
CCRCC	OS	Tertile	III,IV	0.566	0.794	.035	3	view →
UCEC	OS	Quartile	All	1.000	0.849	.044	2	view →
HNSC	DFS	Tertile	II,III,IV	0.991	0.900	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: IARS1 tumor-vs-normal RNA expression · all IARS1 data types