Across TCGA patient cohorts, IARS1 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,731 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IARS1-associated proteins across cancer lineages are MCM2, RRM1, and ANP32B. Each is linked with IARS1 in more than 6 cancer types. Because this analysis shows association rather than direction, both IARS1-to-partner and partner-to-IARS1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IARS1→partner) and Y-score (partner→IARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MCM2 →	+0.609	+0.333	.001	.008	3	7
GBM	RRM1 →	+0.507	+0.406	<.001	<.001	3	7
GBM	ANP32B →	+0.499	+0.564	<.001	<.001	3	7
GBM	SMC2 →	+0.770	+0.514	<.001	<.001	3	7
GBM	MAD2L1 →	+0.614	+0.465	<.001	<.001	3	6
LSCC	NAT10 →	+0.324	+0.453	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,731 associations by consensus.

Exploration

IARS1 survival (RNA) · tumor vs normal (RNA) · all IARS1 data types