Across TCGA patient cohorts, IARS1 protein abundance is significantly associated with the RNA expression of many other genes, with 11,027 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IARS1-associated genes across cancer lineages are ABITRAM, NCBP1, and GPIHBP1. Each is linked with IARS1 in more than 6 cancer types. Because this analysis shows association rather than direction, both IARS1-to-partner and partner-to-IARS1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IARS1→partner) and Y-score (partner→IARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ABITRAM →	+0.528	+0.178	<.001	<.001	3	7
LSCC	NCBP1 →	+0.562	+0.237	<.001	<.001	3	7
CCRCC	GPIHBP1 →	-1.147	-0.211	<.001	<.001	3	7
BRCA	EPRS1 →	+0.545	+0.307	<.001	<.001	3	7
OV	SMC2 →	+0.977	+0.281	<.001	<.001	3	7
LSCC	ZNF367 →	+0.953	+0.227	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,027 associations by consensus.

Exploration

IARS1 survival (RNA) · tumor vs normal (RNA) · all IARS1 data types