Across TCGA patient cohorts, IARS1 protein abundance is significantly associated with the protein abundance of many other proteins, with 25,378 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IARS1-associated proteins across cancer lineages are ABCE1, EIF5B, and EPRS1. Each is linked with IARS1 in more than 9 cancer types. Because this analysis shows association rather than direction, both IARS1-to-partner and partner-to-IARS1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IARS1→partner) and Y-score (partner→IARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ABCE1 →	+0.299	+0.226	<.001	<.001	3	10
OV	EIF5B →	+0.316	+0.348	<.001	<.001	3	10
GBM	EPRS1 →	+0.283	+0.314	<.001	<.001	3	10
OV	RPL10A →	+0.348	+0.313	<.001	.001	3	10
HNSC	RPS4X →	+0.527	+0.216	<.001	<.001	3	10
OV	LARS1 →	+0.396	+0.306	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 25,378 associations by consensus.

Exploration

IARS1 survival (RNA) · tumor vs normal (RNA) · all IARS1 data types