Across TCGA patient cohorts, IARS1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IARS1-associated genes across cancer lineages are ATM, Gab2, and Annexin_VII. Each is linked with IARS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both IARS1-to-partner and partner-to-IARS1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IARS1→partner) and Y-score (partner→IARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.435	-1.222	.003	.035	3	3
SKCM	Gab2 →	+0.610	+3.000	.007	.036	3	2
SKCM	Annexin_VII →	-0.204	-3.000	.017	.036	3	2
SKCM	CDK1 →	+0.277	+3.000	.005	.036	3	2
UCEC	eIF4E →	+0.224	+2.000	.001	<.001	3	2
UCEC	ERK2 →	+0.171	+2.700	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Exploration

IARS1 survival (RNA) · tumor vs normal (RNA) · all IARS1 data types