Across TCGA cell cohorts, IARS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,327 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IARS1-associated GO terms across cancer lineages are Positive regulation of mRNA 3'-end processing, L-serine biosynthetic process, and Serine family amino acid biosynthetic process. Each is linked with IARS1 in more than 13 cancer types. Because this analysis shows association rather than direction, both IARS1-to-partner and partner-to-IARS1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IARS1→partner) and Y-score (partner→IARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of mRNA 3'-end processing →	+0.138	+0.904	<.001	<.001	3	14
BREAST	L-serine biosynthetic process →	+0.205	+0.618	.008	<.001	3	13
BLOOD_Leukemia	Serine family amino acid biosynthetic process →	+0.168	+0.910	<.001	<.001	3	13
CNS	tRNA transport →	+0.105	+0.630	<.001	<.001	3	13
LARGE_INTESTINE	Formate biosynthetic process →	+0.142	+0.951	<.001	<.001	3	12
LUNG_SCLC	Protein localization to kinetochore →	+0.102	+0.632	.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,327 associations by consensus.

Exploration

IARS1 survival (RNA) · tumor vs normal (RNA) · all IARS1 data types