Across TCGA cell cohorts, IARS1 mutation is significantly associated with the RNA expression of many other genes, with 574 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IARS1-associated genes across cancer lineages are OR13C5, KCNA10, and OR6K3. Each is linked with IARS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IARS1-to-partner and partner-to-IARS1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IARS1→partner) and Y-score (partner→IARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	OR13C5 →	+0.023	+5.000	<.001	.005	3	2
KIDNEY	KCNA10 →	+0.013	+5.000	<.001	.005	3	1
BLOOD_Myeloma	OR6K3 →	+0.036	+4.285	<.001	.003	3	1
BLOOD_Myeloma	GPR33 →	+0.085	+3.906	<.001	.009	3	1
BLOOD_Myeloma	C2orf83 →	+0.028	+3.906	.003	.009	3	1
BLOOD_Leukemia	NPTX2 →	+1.367	+3.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 574 associations by consensus.

Exploration

IARS1 survival (RNA) · tumor vs normal (RNA) · all IARS1 data types