IAPP

Across TCGA pan-cancer cohorts, IAPP mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated IAPP data layer compared with 19 for mass-spec protein.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher IAPP mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IAPP expression acts as an unfavorable survival marker.

PDAC are the cancer types where IAPP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.205	0.338	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

IAPP–PDAC (DFS)

Open the PDAC breakdown →