IAPP

Across TCGA patient cohorts, IAPP RNA expression is significantly associated with the protein abundance of many other proteins, with 10,803 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IAPP-associated proteins across cancer lineages are USP20_S333, NT5E, and EHD1. Each is linked with IAPP in more than 3 cancer types. Because this analysis shows association rather than direction, both IAPP-to-partner and partner-to-IAPP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IAPP versus USP20_S333 in LUAD, with a Pearson correlation of -0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IAPP→partner) and Y-score (partner→IAPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	USP20_S333 →	-0.496	-0.373	<.001	.004	3	4
PDAC	NT5E →	-0.692	-1.124	<.001	.002	3	4
HNSC	EHD1 →	-0.342	-0.844	<.001	<.001	3	4
LUAD	IGF2BP3 →	+1.367	+0.242	<.001	.001	3	4
LSCC	VPS13C_S3702 →	-0.642	-0.926	<.001	<.001	3	3
LSCC	WNK2_S1862 →	+1.321	+0.998	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,803 associations by consensus.

IAPP vs USP20_S333 — LUAD

Explore this scatter interactively →