IAPP

Across TCGA patient cohorts, IAPP mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IAPP-associated genes across cancer lineages are OR2M7, KRTAP21-2, and STMN1P1. Each is linked with IAPP in more than 1 cancer types. Because this analysis shows association rather than direction, both IAPP-to-partner and partner-to-IAPP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2M7 grouped by IAPP-low versus IAPP-high in SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IAPP→partner) and Y-score (partner→IAPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	OR2M7 →	+0.119	+5.624	<.001	.003	3	1
SCLC	KRTAP21-2 →	+0.486	+5.624	<.001	.003	3	1
UCEC	STMN1P1 →	+0.460	+3.330	.007	.009	3	1
UCEC	HNRNPCL3 →	+0.050	+2.871	.001	.007	3	1
UCEC	FER1L6-AS1 →	+0.061	+3.160	.004	.002	3	1
UCEC	AQP7P1 →	+0.431	+3.500	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

OR2M7 by IAPP expression — SCLC

Explore this box plot interactively →