IAPP

Across TCGA patient cohorts, IAPP mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IAPP-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, JNK_pT183_Y185, and Ku80. Each is linked with IAPP in more than 1 cancer types. Because this analysis shows association rather than direction, both IAPP-to-partner and partner-to-IAPP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by IAPP-low versus IAPP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IAPP→partner) and Y-score (partner→IAPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.617	+2.817	.035	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.231	-2.986	.017	.037	3	1
UCEC	Ku80 →	+0.297	+3.013	.029	.019	3	1
UCEC	Notch1 →	+0.261	+2.817	.001	.036	3	1
UCEC	STAT3_pY705 →	-0.530	-3.000	<.001	.037	3	1
UCEC	PDCD4 →	-0.721	-3.000	.008	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Acetyl-a-Tubulin-Lys40 by IAPP expression — UCEC

Explore this box plot interactively →