IAPP

Across TCGA cell cohorts, IAPP RNA expression is significantly associated with the mutation status of many other genes, with 98 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IAPP-associated genes across cancer lineages are PRKDC, ADAM29, and ABCA6. Each is linked with IAPP in more than 1 cancer types. Because this analysis shows association rather than direction, both IAPP-to-partner and partner-to-IAPP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRKDC grouped by IAPP-low versus IAPP-high in URINARY_TRACT.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IAPP→partner) and Y-score (partner→IAPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PRKDC →	+3.321	+0.144	.003	.003	3	2
BLOOD_Leukemia	ADAM29 →	+3.857	+0.045	<.001	<.001	3	2
SKIN	ABCA6 →	+4.054	+0.123	.004	<.001	3	2
SKIN	NRCAM →	+2.791	+0.062	.005	.006	3	2
LARGE_INTESTINE	FAM71B →	+3.228	+0.412	.003	<.001	3	2
LARGE_INTESTINE	RNF4 →	+4.228	+0.466	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 98 associations by consensus.

PRKDC by IAPP expression — URINARY_TRACT

Explore this box plot interactively →