IAH1

Across TCGA pan-cancer cohorts, IAH1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of IAH1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IAH1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types IAH1 is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

COAD, PDAC, and LSCC are the cancer types where IAH1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IAH1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−0.517	<.001	9	view →
PDAC	Male	All	+0.600	<.001	6	view →
LSCC	Male	All	−0.313	<.001	6	view →
HNSC	All	III,IV	−0.276	<.001	6	view →
CCRCC	All	All	+0.105	.003	6	view →
LUAD	All	II,III,IV	−0.113	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

IAH1–COAD

Open the COAD breakdown →