Across TCGA patient cohorts, HYLS1 protein abundance is significantly associated with the RNA expression of many other genes, with 1,162 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HYLS1-associated genes across cancer lineages are BOLA3P3, PYGB, and RPL19. Each is linked with HYLS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HYLS1-to-partner and partner-to-HYLS1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYLS1→partner) and Y-score (partner→HYLS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BOLA3P3 →	+0.617	+0.416	<.001	<.001	3	2
LUAD	PYGB →	-1.070	-0.747	<.001	.005	3	1
LUAD	RPL19 →	-0.524	-0.700	.009	.006	3	1
LUAD	RPL34 →	-0.487	-0.487	.001	.005	3	1
LUAD	ABHD14A-ACY1 →	-0.055	-0.475	.007	.008	3	1
LUAD	TP53I3 →	-0.803	-0.539	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,162 associations by consensus.

Exploration

HYLS1 survival (RNA) · tumor vs normal (RNA) · all HYLS1 data types