Across TCGA patient cohorts, HYLS1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HYLS1-associated genes across cancer lineages are Rad50, STAT3_pY705, and EGFR_pY1068. Each is linked with HYLS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HYLS1-to-partner and partner-to-HYLS1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYLS1→partner) and Y-score (partner→HYLS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.224	-3.169	.029	.019	3	2
UCEC	STAT3_pY705 →	-0.380	-2.459	<.001	.018	3	2
UCEC	EGFR_pY1068 →	-0.214	-2.222	.044	.011	3	1
UCEC	FASN →	+0.446	+3.459	.007	.005	3	1
UCEC	FoxM1 →	+0.306	+2.906	.005	.001	3	1
UCEC	INPP4B →	-0.323	-3.321	.018	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

HYLS1 survival (RNA) · tumor vs normal (RNA) · all HYLS1 data types