Across TCGA pan-cancer cohorts, HYKK Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated HYKK data layer compared with 21 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher HYKK Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated HYKK expression acts as an unfavorable survival marker.

SKCM are the cancer types where HYKK Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	III,IV	0.015	0.648	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: HYKK tumor-vs-normal RNA expression · all HYKK data types