Across TCGA pan-cancer cohorts, HYKK mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HYKK data layer compared with 21 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HYKK mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HYKK expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

CCRCC, HNSC, and LSCC are the cancer types where HYKK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	0.938	0.609	.011	5	view →
HNSC	OS	Quartile	All	0.482	0.813	.038	4	view →
LSCC	DFS	Median	III,IV	0.391	0.854	.011	4	view →
LUAD	DFS	Quartile	All	0.283	0.806	.013	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: HYKK tumor-vs-normal RNA expression · all HYKK data types