Across TCGA patient cohorts, HYKK RNA expression is significantly associated with the protein abundance of many other proteins, with 19,615 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HYKK-associated proteins across cancer lineages are RIPK2, GATAD2B, and ANP32A. Each is linked with HYKK in more than 4 cancer types. Because this analysis shows association rather than direction, both HYKK-to-partner and partner-to-HYKK results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HYKK→partner) and Y-score (partner→HYKK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RIPK2 →	-0.394	-0.577	<.001	<.001	3	5
HNSC	GATAD2B →	+0.357	+0.607	<.001	<.001	3	5
LSCC	ANP32A →	+0.348	+0.597	<.001	<.001	3	5
LSCC	SPR →	+0.404	+0.549	<.001	<.001	3	4
LSCC	HSD17B10 →	+0.367	+0.498	<.001	.001	3	4
LSCC	TRIM28 →	+0.345	+0.598	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,615 associations by consensus.

Exploration

HYKK survival (RNA) · tumor vs normal (RNA) · all HYKK data types