Across TCGA patient cohorts, HYKK protein abundance is significantly associated with the RNA expression of many other genes, with 4,114 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HYKK-associated genes across cancer lineages are ITGB2-AS1, WNT10A, and SPEF2. Each is linked with HYKK in more than 2 cancer types. Because this analysis shows association rather than direction, both HYKK-to-partner and partner-to-HYKK results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYKK→partner) and Y-score (partner→HYKK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ITGB2-AS1 →	-0.880	-0.354	.001	.003	3	3
UCEC	WNT10A →	-1.227	-0.320	.001	.005	3	2
GBM	SPEF2 →	+0.836	+0.377	.006	.005	3	2
UCEC	OBSCN →	-0.786	-0.427	.003	.002	3	2
UCEC	CHST11 →	-0.811	-0.325	<.001	<.001	3	2
UCEC	PARP14 →	-0.728	-0.307	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,114 associations by consensus.

Exploration

HYKK survival (RNA) · tumor vs normal (RNA) · all HYKK data types