Across TCGA patient cohorts, HYKK mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HYKK-associated genes across cancer lineages are eEF2, ERK2, and ETS-1. Each is linked with HYKK in more than 1 cancer types. Because this analysis shows association rather than direction, both HYKK-to-partner and partner-to-HYKK results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYKK→partner) and Y-score (partner→HYKK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.663	+3.321	<.001	.010	3	1
UCEC	ERK2 →	+0.239	+2.459	.010	.020	3	1
UCEC	ETS-1 →	+0.409	+2.459	.007	.020	3	1
UCEC	Heregulin →	-0.182	-3.156	.002	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.204	-3.000	.012	.036	3	1
UCEC	JNK2 →	+0.254	+2.459	.008	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration

HYKK survival (RNA) · tumor vs normal (RNA) · all HYKK data types