HYI

Across TCGA patient cohorts, HYI protein abundance is significantly associated with the RNA expression of many other genes, with 17,469 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HYI-associated genes across cancer lineages are TNS2, TTK, and C7. Each is linked with HYI in more than 7 cancer types. Because this analysis shows association rather than direction, both HYI-to-partner and partner-to-HYI results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HYI versus TNS2 in BRCA, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYI→partner) and Y-score (partner→HYI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TNS2 →	+1.269	+0.488	<.001	<.001	3	8
LSCC	TTK →	-0.971	-0.330	<.001	.002	3	7
UCEC	C7 →	+2.449	+0.336	<.001	<.001	3	7
UCEC	MTFR2 →	-1.043	-0.370	<.001	<.001	3	7
UCEC	SKA1 →	-1.085	-0.384	<.001	<.001	3	7
LUAD	MELK →	-1.183	-0.332	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,469 associations by consensus.

HYI vs TNS2 — BRCA

Explore this scatter interactively →