HYI

Across TCGA patient cohorts, HYI mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HYI-associated genes across cancer lineages are RNA5SP414, RPL7L1P11, and ATP6V1E1P2. Each is linked with HYI in more than 1 cancer types. Because this analysis shows association rather than direction, both HYI-to-partner and partner-to-HYI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP414 grouped by HYI-low versus HYI-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYI→partner) and Y-score (partner→HYI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP414 →	+1.015	+3.840	<.001	.007	3	1
UCEC	RPL7L1P11 →	+0.165	+4.184	.005	.004	3	1
UCEC	ATP6V1E1P2 →	+0.267	+3.661	.001	.009	3	1
UCEC	OR2E1P →	+0.160	+4.442	<.001	.007	3	1
UCEC	EIF3JP1 →	+0.701	+3.690	<.001	.009	3	1
UCEC	TXNP3 →	+0.290	+4.223	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

RNA5SP414 by HYI expression — UCEC

Explore this box plot interactively →