Across TCGA pan-cancer cohorts, HYI-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated HYI-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher HYI-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HYI-AS1 expression acts as an unfavorable survival marker, although some lineages such as DLBC and UCEC show a favorable association.

ACC, KIRC, and LGG are the cancer types where HYI-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.199	0.705	<.001	155	view →
KIRC	DFS	Median	All	0.765	0.836	.004	78	view →
LGG	DFS	Median	All	0.642	0.827	<.001	41	view →
UCS	DFS	Median	IV	0.367	0.952	.001	36	view →
BRCA	DFS	Tertile	All	0.860	0.926	.001	32	view →
PRAD	DFS	Median	All	0.710	0.867	<.001	28	view →
LIHC	OS	Tertile	All	0.710	0.832	.011	23	view →
DLBC	DFS	Median	III,IV	1.000	0.525	.013	22	view →
UCEC	OS	Quartile	All	0.760	0.686	.003	22	view →
SKCM	DFS	Tertile	All	0.151	0.323	.007	21	view →
CHOL	DFS	Median	All	0.184	0.645	.003	18	view →
HNSC	OS	Tertile	II,III,IV	0.815	0.697	.002	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

Exploration

Same gene, other analysis: HYI-AS1 tumor-vs-normal RNA expression · all HYI-AS1 data types