HYDIN

Across TCGA pan-cancer cohorts, HYDIN Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated HYDIN data layer compared with 21 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HYDIN Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated HYDIN expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

UCEC, COAD, and CESC are the cancer types where HYDIN Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.918	0.417	.003	32	view →
COAD	OS	Median	IV	0.089	0.649	.005	20	view →
CESC	DFS	Median	All	0.605	0.834	.001	18	view →
ACC	DFS	Median	IV	0.010	0.383	<.001	18	view →
LIHC	DFS	Median	II,III,IV	0.146	0.436	.004	10	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
SARC	DFS	Median	All	0.279	0.622	<.001	9	view →
READ	OS	Median	IV	0.289	0.899	<.001	6	view →
PRAD	DFS	Median	All	0.604	0.888	.003	6	view →
SKCM	OS	Median	IV	0.133	0.621	.019	5	view →
STAD	DFS	Median	III,IV	0.787	0.303	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

HYDIN–UCEC (DFS)

Open the UCEC breakdown →