HYDIN

Across TCGA pan-cancer cohorts, HYDIN mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HYDIN data layer compared with 21 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher HYDIN mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HYDIN expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where HYDIN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	III,IV	0.941	0.250	.003	20	view →
PDAC	OS	Tertile	II,III,IV	0.480	0.222	.030	18	view →
LUAD	DFS	Median	III,IV	0.132	1.000	.038	6	view →
UCEC	DFS	Median	All	0.720	1.000	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HYDIN–LSCC (DFS)

Open the LSCC breakdown →