HYAL4

Across TCGA patient cohorts, HYAL4 mutation is significantly associated with the RNA expression of many other genes, with 3,085 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HYAL4-associated genes across cancer lineages are TBC1D3G, IFNA16, and SNRPD3. Each is linked with HYAL4 in more than 2 cancer types. Because this analysis shows association rather than direction, both HYAL4-to-partner and partner-to-HYAL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D3G grouped by HYAL4-low versus HYAL4-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYAL4→partner) and Y-score (partner→HYAL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	TBC1D3G →	+0.041	+3.296	<.001	.004	3	3
HNSC	IFNA16 →	+0.026	+4.936	.005	.003	3	2
SKCM	SNRPD3 →	+0.373	+2.502	<.001	.001	3	2
UCEC	PES1 →	+0.520	+3.277	<.001	<.001	3	2
UCEC	RTCB →	+0.488	+3.054	<.001	<.001	3	2
UCEC	PPP6R2 →	+0.369	+2.136	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,085 associations by consensus.

TBC1D3G by HYAL4 expression — LUSC

Explore this box plot interactively →