HYAL4

Across TCGA patient cohorts, HYAL4 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HYAL4-associated genes across cancer lineages are 4E-BP1, JNK2, and 4E-BP1_pS65. Each is linked with HYAL4 in more than 2 cancer types. Because this analysis shows association rather than direction, both HYAL4-to-partner and partner-to-HYAL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by HYAL4-low versus HYAL4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYAL4→partner) and Y-score (partner→HYAL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	4E-BP1 →	+0.323	+3.169	.017	.018	3	3
UCEC	JNK2 →	+0.266	+2.523	<.001	<.001	3	2
SKCM	4E-BP1_pS65 →	+0.208	+2.000	.019	.031	3	2
SKCM	C-Raf →	+0.140	+2.000	.024	.031	3	2
UCEC	JNK_pT183_Y185 →	-0.183	-2.807	.001	.003	3	2
UCEC	TFRC →	+0.576	+2.700	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

4E-BP1 by HYAL4 expression — SKCM

Explore this box plot interactively →