HYAL4

Across TCGA cell cohorts, HYAL4 RNA expression is significantly associated with the go_rna of many other GO terms, with 647 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HYAL4-associated GO terms across cancer lineages are Regulation of response to type II interferon, Regulation of type II interferon-mediated signaling pathway, and Negative regulation of innate immune response. Each is linked with HYAL4 in more than 6 cancer types. Because this analysis shows association rather than direction, both HYAL4-to-partner and partner-to-HYAL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of response to type II interferon grouped by HYAL4-low versus HYAL4-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HYAL4→partner) and Y-score (partner→HYAL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of response to type II interferon →	+0.201	+0.233	<.001	.005	3	7
LUNG_NSCLC_LUSC	Regulation of type II interferon-mediated signaling pathway →	+0.201	+0.233	<.001	.005	3	7
BREAST	Negative regulation of innate immune response →	+0.093	+0.527	.001	.008	3	6
BREAST	Cell-substrate junction organization →	+0.154	+0.553	<.001	.005	3	6
PANCREAS	Regulation of response to cytokine stimulus →	+0.076	+0.753	<.001	.003	2	6
LIVER	Positive regulation of chromatin binding →	+0.294	+1.040	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 647 associations by consensus.

Regulation of response to type II interferon by HYAL4 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →