HYAL4

Across TCGA cell cohorts, HYAL4 mutation is significantly associated with the RNA expression of many other genes, with 179 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HYAL4-associated genes across cancer lineages are DESI1, R3HCC1, and SLC25A11. Each is linked with HYAL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HYAL4-to-partner and partner-to-HYAL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DESI1 grouped by HYAL4-low versus HYAL4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYAL4→partner) and Y-score (partner→HYAL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DESI1 →	+0.553	+2.451	<.001	.009	3	1
LARGE_INTESTINE	R3HCC1 →	+0.825	+3.237	<.001	.003	3	1
LARGE_INTESTINE	SLC25A11 →	+0.739	+3.502	<.001	.001	3	1
LARGE_INTESTINE	PRDM4 →	+0.522	+3.588	.001	<.001	3	1
LARGE_INTESTINE	GTF2H3 →	+0.629	+2.451	.004	.009	3	1
LARGE_INTESTINE	UHRF1BP1L →	+0.606	+3.082	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 179 associations by consensus.

DESI1 by HYAL4 expression — LARGE_INTESTINE

Explore this box plot interactively →