Across TCGA pan-cancer cohorts, HYAL3 mass-spec protein differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of HYAL3’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where HYAL3 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types HYAL3 is over-expressed in tumor, although a few such as LSCC show the opposite, repressed pattern.

LSCC are the cancer types where HYAL3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HYAL3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	−0.598	.007	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: HYAL3 RNA expression & survival · all HYAL3 data types