Across TCGA patient cohorts, HYAL3 protein abundance is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible HYAL3-associated genes across cancer lineages are CHRDL1, CCNG1, and KLK14. Each is linked with HYAL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HYAL3-to-partner and partner-to-HYAL3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYAL3→partner) and Y-score (partner→HYAL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CHRDL1 →	-2.064	-1.029	.001	.003	3	1
HNSC	CCNG1 →	-0.821	-0.792	.003	.001	3	1
HNSC	KLK14 →	+2.066	+0.796	.006	.005	3	1
HNSC	RRP8 →	-0.710	-1.271	.001	.004	3	1
HNSC	GLRA1 →	-0.595	-0.815	<.001	.001	3	1
HNSC	PHOX2A →	-0.176	-0.760	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Exploration

HYAL3 survival (RNA) · tumor vs normal (RNA) · all HYAL3 data types