Across TCGA patient cohorts, HYAL3 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HYAL3-associated genes across cancer lineages are p62 Lck ligand, Bak, and Caspase-7-cleavedD198. Each is linked with HYAL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HYAL3-to-partner and partner-to-HYAL3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYAL3→partner) and Y-score (partner→HYAL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.437	+3.179	.003	.010	3	2
UCEC	Bak →	+0.298	+3.169	.010	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.992	+3.700	<.001	.001	3	2
UCEC	eEF2 →	+0.496	+2.584	.002	.011	3	1
UCEC	eIF4E →	+0.239	+2.820	.015	.035	3	1
UCEC	JNK2 →	+0.240	+2.584	.009	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Exploration

HYAL3 survival (RNA) · tumor vs normal (RNA) · all HYAL3 data types