Across TCGA cell cohorts, HYAL3 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Myeloma shows the largest number of these associations.

The most reproducible HYAL3-associated genes across cancer lineages are LRRC74A, SERPINA7, and C1orf158. Each is linked with HYAL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HYAL3-to-partner and partner-to-HYAL3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYAL3→partner) and Y-score (partner→HYAL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	LRRC74A →	+0.013	+4.807	<.001	.006	3	1
BLOOD_Myeloma	SERPINA7 →	+0.459	+4.807	<.001	.006	3	1
BLOOD_Myeloma	C1orf158 →	+0.053	+4.807	<.001	.006	3	1
LARGE_INTESTINE	DEFA1 →	+0.248	+3.920	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

HYAL3 survival (RNA) · tumor vs normal (RNA) · all HYAL3 data types