HYAL2

Across TCGA patient cohorts, HYAL2 protein abundance is significantly associated with the RNA expression of many other genes, with 3,249 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HYAL2-associated genes across cancer lineages are TMED9, CDKN1A, and ITPRIP. Each is linked with HYAL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HYAL2-to-partner and partner-to-HYAL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HYAL2 versus TMED9 in GBM, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYAL2→partner) and Y-score (partner→HYAL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TMED9 →	+0.332	+0.298	.001	.001	3	3
GBM	CDKN1A →	+0.785	+0.249	<.001	<.001	3	3
LSCC	ITPRIP →	+0.518	+0.209	.001	.001	3	3
BRCA	SPRY1 →	+1.174	+0.489	.003	.001	3	3
BRCA	HEPH →	+1.098	+0.413	.003	.005	3	3
BRCA	EMP1 →	+1.242	+0.414	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,249 associations by consensus.

HYAL2 vs TMED9 — GBM

Explore this scatter interactively →