HYAL2

Across TCGA patient cohorts, HYAL2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HYAL2-associated genes across cancer lineages are Annexin-1, MSH2, and mTOR_pS2448. Each is linked with HYAL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HYAL2-to-partner and partner-to-HYAL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by HYAL2-low versus HYAL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYAL2→partner) and Y-score (partner→HYAL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.706	+3.019	.003	.019	3	2
UCEC	MSH2 →	-0.305	-2.973	.004	.035	3	1
UCEC	mTOR_pS2448 →	-0.170	-2.302	.014	.034	3	1
UCEC	Notch1 →	+0.214	+2.179	.001	.034	3	1
UCEC	PDCD4 →	-0.533	-2.999	.015	.035	3	1
UCEC	Rictor_pT1135 →	-0.096	-2.584	.044	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Annexin-1 by HYAL2 expression — UCEC

Explore this box plot interactively →