HYAL2

Across TCGA cell cohorts, HYAL2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible HYAL2-associated genes across cancer lineages are TPD52L3, SPRR4, and USP17L15. Each is linked with HYAL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HYAL2-to-partner and partner-to-HYAL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TPD52L3 grouped by HYAL2-low versus HYAL2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYAL2→partner) and Y-score (partner→HYAL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TPD52L3 →	+0.526	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	SPRR4 →	+0.031	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	USP17L15 →	+0.016	+5.228	<.001	.005	3	1
LARGE_INTESTINE	SIGLECL1 →	+0.022	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TPD52L3 by HYAL2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →