HYAL1

Across TCGA pan-cancer cohorts, HYAL1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HYAL1 data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HYAL1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HYAL1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where HYAL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.927	0.681	.005	14	view →
PDAC	DFS	Quartile	All	0.895	0.281	.001	13	view →
HNSC	OS	Tertile	II,III,IV	0.988	0.838	.015	11	view →
LSCC	DFS	Tertile	All	1.000	0.448	.006	8	view →
GBM	OS	Median	All	0.349	0.784	.017	5	view →
LUAD	DFS	Quartile	All	0.927	0.995	.017	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HYAL1–CCRCC (DFS)

Open the CCRCC breakdown →