HVCN1

Across TCGA pan-cancer cohorts, HVCN1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HVCN1 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HVCN1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HVCN1 expression acts as an unfavorable survival marker, although some lineages such as OV show a favorable association.

COAD, CCRCC, and PDAC are the cancer types where HVCN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.896	1.000	.037	24	view →
CCRCC	DFS	Median	IV	0.227	0.915	.006	15	view →
PDAC	DFS	Median	II,III,IV	0.646	0.812	.013	6	view →
OV	DFS	Tertile	All	0.923	0.621	.037	4	view →
UCEC	DFS	Tertile	All	0.823	0.967	.015	4	view →
GBM	DFS	Tertile	All	0.625	0.795	.020	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HVCN1–COAD (DFS)

Open the COAD breakdown →