HVCN1

Across TCGA cell cohorts, HVCN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,598 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HVCN1-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, RNA splicing, via transesterification reactions with bulged adenosine as nucleophile, and mRNA splicing, via spliceosome. Each is linked with HVCN1 in more than 8 cancer types. Because this analysis shows association rather than direction, both HVCN1-to-partner and partner-to-HVCN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by HVCN1-low versus HVCN1-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HVCN1→partner) and Y-score (partner→HVCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Negative regulation of myoblast fusion →	+0.097	+0.551	<.001	<.001	3	9
OVARY	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.048	+0.430	<.001	.007	3	9
OVARY	mRNA splicing, via spliceosome →	+0.048	+0.430	<.001	.007	3	9
PANCREAS	Regulation of protein localization to mitochondrion →	+0.112	+1.052	<.001	<.001	3	8
SOFT_TISSUE	Maintenance of protein location in cell →	+0.164	+1.181	<.001	<.001	3	8
SKIN	Negative regulation of syncytium formation by plasma membrane fusion →	+0.097	+0.544	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,598 associations by consensus.

Negative regulation of myoblast fusion by HVCN1 expression — SKIN

Explore this box plot interactively →