HVCN1

Across TCGA cell cohorts, HVCN1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible HVCN1-associated genes across cancer lineages are OR10T2, RESP18, and OR10R2. Each is linked with HVCN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HVCN1-to-partner and partner-to-HVCN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10T2 grouped by HVCN1-low versus HVCN1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HVCN1→partner) and Y-score (partner→HVCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR10T2 →	+1.035	+4.276	<.001	.007	3	2
BLOOD_Lymphoma	RESP18 →	+0.055	+5.209	<.001	.005	3	1
BLOOD_Leukemia	OR10R2 →	+2.141	+4.551	<.001	.004	3	1
BREAST	OR10K2 →	+0.063	+5.781	<.001	.001	3	1
BREAST	PABPC1L2A →	+0.083	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OR10T2 by HVCN1 expression — BLOOD_Leukemia

Explore this box plot interactively →