HUWE1

Across TCGA pan-cancer cohorts, HUWE1 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated HUWE1 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher HUWE1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HUWE1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SCLC show a favorable association.

THYM, KICH, and UCEC are the cancer types where HUWE1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
KICH	DFS	Median	All	0.081	0.904	<.001	30	view →
UCEC	DFS	Median	II,III,IV	0.859	0.422	.010	22	view →
LIHC	OS	Median	All	0.280	0.694	.003	21	view →
THCA	DFS	Median	II,III,IV	0.103	0.928	<.001	12	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
BRCA	OS	Median	All	0.835	0.926	.009	8	view →
ESCA	OS	Median	II,III,IV	0.105	0.867	.016	6	view →
SCLC	DFS	Median	All	1.000	0.431	.012	4	view →
SKCM	OS	Median	IV	0.415	0.861	.014	3	view →
OV	DFS	Median	III,IV	0.407	0.147	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

HUWE1–THYM (OS)

Open the THYM breakdown →