HUWE1

Across TCGA pan-cancer cohorts, HUWE1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HUWE1 data layer compared with 24 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HUWE1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HUWE1 expression acts as an unfavorable survival marker.

HNSC, CCRCC, and PDAC are the cancer types where HUWE1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.316	0.886	.012	34	view →
CCRCC	OS	Median	All	0.837	0.946	.009	21	view →
PDAC	DFS	Quartile	All	0.609	0.922	.005	17	view →
LUAD	DFS	Tertile	II,III,IV	0.380	1.000	.015	15	view →
LSCC	DFS	Median	All	0.722	0.853	.019	8	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HUWE1–HNSC (DFS)

Open the HNSC breakdown →