Across TCGA patient cohorts, HUS1B mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HUS1B-associated genes across cancer lineages are Shc_pY317, JNK_pT183_Y185, and HER3. Each is linked with HUS1B in more than 2 cancer types. Because this analysis shows association rather than direction, both HUS1B-to-partner and partner-to-HUS1B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HUS1B→partner) and Y-score (partner→HUS1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.191	-3.000	.016	.036	3	3
UCEC	JNK_pT183_Y185 →	-0.191	-3.000	.030	.036	3	2
UCEC	HER3 →	-0.324	-3.308	.024	.010	3	1
UCEC	Heregulin →	-0.207	-3.000	.001	.036	3	1
UCEC	Tuberin →	+0.365	+3.321	.009	.010	3	1
UCEC	ATM →	-0.703	-3.321	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

HUS1B survival (RNA) · tumor vs normal (RNA) · all HUS1B data types