Across TCGA cell cohorts, HUS1B mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HUS1B-associated genes across cancer lineages are VSX2, IL22, and SPATA48. Each is linked with HUS1B in more than 1 cancer types. Because this analysis shows association rather than direction, both HUS1B-to-partner and partner-to-HUS1B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HUS1B→partner) and Y-score (partner→HUS1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	VSX2 →	+0.024	+3.258	.001	.007	3	1
BLOOD_Leukemia	IL22 →	+0.021	+4.247	<.001	.004	3	1
BLOOD_Leukemia	SPATA48 →	+0.572	+3.474	.005	.007	3	1
BLOOD_Leukemia	UCMA →	+0.081	+2.926	<.001	.009	3	1
BLOOD_Leukemia	PRSS42P →	+0.103	+3.630	.004	.006	3	1
BLOOD_Leukemia	PRSS50 →	+0.020	+3.744	.008	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

HUS1B survival (RNA) · tumor vs normal (RNA) · all HUS1B data types