HUS1

Across TCGA pan-cancer cohorts, HUS1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of HUS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where HUS1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types HUS1 is over-expressed in tumor.

LUAD, LSCC, and HNSC are the cancer types where HUS1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HUS1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	+0.510	<.001	9	view →
LSCC	Male	All	+0.493	<.001	9	view →
HNSC	Male	IV	+0.485	<.001	8	view →
CCRCC	Male	III,IV	+0.191	.001	8	view →
OV	All	All	+0.506	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

HUS1–LUAD

Open the LUAD breakdown →