HUS1

Across TCGA cell cohorts, HUS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,460 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HUS1-associated GO terms across cancer lineages are Meiotic cell cycle checkpoint signaling, Regulation of mitotic sister chromatid separation, and Mitotic nuclear division. Each is linked with HUS1 in more than 14 cancer types. Because this analysis shows association rather than direction, both HUS1-to-partner and partner-to-HUS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Meiotic cell cycle checkpoint signaling grouped by HUS1-low versus HUS1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HUS1→partner) and Y-score (partner→HUS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Meiotic cell cycle checkpoint signaling →	+0.232	+1.012	<.001	<.001	3	15
PANCREAS	Regulation of mitotic sister chromatid separation →	+0.122	+0.876	.003	.001	3	10
PANCREAS	Mitotic nuclear division →	+0.071	+0.716	.004	<.001	3	10
OESOPHAGUS	Regulation of mitotic spindle checkpoint →	+0.108	+0.830	.001	.001	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of mitotic metaphase/anaphase transition →	+0.113	+0.757	.005	.006	2	11
PANCREAS	Spindle checkpoint signaling →	+0.119	+0.778	.007	.004	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,460 associations by consensus.

Meiotic cell cycle checkpoint signaling by HUS1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →