HUNK

Across TCGA patient cohorts, HUNK mutation is significantly associated with the RNA expression of many other genes, with 4,514 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HUNK-associated genes across cancer lineages are DTYMK, UFD1, and WDR62. Each is linked with HUNK in more than 2 cancer types. Because this analysis shows association rather than direction, both HUNK-to-partner and partner-to-HUNK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DTYMK grouped by HUNK-low versus HUNK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HUNK→partner) and Y-score (partner→HUNK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DTYMK →	+0.422	+1.538	.001	.003	3	3
SKCM	UFD1 →	+0.414	+3.360	.001	.004	3	3
UCEC	WDR62 →	+0.608	+4.191	<.001	<.001	3	3
UCEC	MRPL22 →	+0.283	+3.313	<.001	<.001	3	3
UCEC	RPL23AP82 →	+0.471	+4.343	<.001	<.001	3	3
UCEC	ZWINT →	+0.648	+3.169	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,514 associations by consensus.

DTYMK by HUNK expression — UCEC

Explore this box plot interactively →