HUNK

Across TCGA patient cohorts, HUNK mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HUNK-associated genes across cancer lineages are PAI-1, PDCD4, and Stathmin. Each is linked with HUNK in more than 2 cancer types. Because this analysis shows association rather than direction, both HUNK-to-partner and partner-to-HUNK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAI-1 grouped by HUNK-low versus HUNK-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HUNK→partner) and Y-score (partner→HUNK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PAI-1 →	+0.724	+3.008	.018	.019	3	2
COAD	PDCD4 →	-0.752	-2.991	<.001	.036	3	2
COAD	Stathmin →	+0.159	+3.008	.045	.019	3	2
COAD	ASNS →	+0.732	+3.008	<.001	.019	3	2
UCEC	eIF4E →	+0.193	+3.598	.007	.001	3	2
UCEC	Rad50 →	-0.242	-1.807	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

PAI-1 by HUNK expression — COAD

Explore this box plot interactively →